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Wiley Interdiscip Rev Cogn Sci 2017;8:e1427

This can significantly improve therapeutic efficacy, reduce the risk of drug resistance, and limit nonspecific inflammatory damage (Tang et al., 2022)

KPV (LysineProlineValine) is a naturally derived tripeptide and the Cterminal fragment of alpha melanocyte stimulating hormone (MSH)

In NSCLC, MEG3 suppresses tumor proliferation and metastasis via the miR-21-5p/PTEN and MDM2/p53 axes, while in pulmonary hypertension, it promotes vascular remodeling by sponging miR-328-3p and upregulating IGF1R, highlighting its dual context-dependent roles in tumor suppression and vascular dysfunction [109,110,111]